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It reduced exacerbations, or lung attacks, and significantly improved lung function, in a patient population whose lung function is very poor.
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Breathing becomes severely compromised and patients may need to be admitted to a hospital.
Roflumilast acts differently to bronchodilators as it acts on the underlying condition, not primarily impacting on everyday symptoms.
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These eagerly awaited results, published this week in The Lancet, show that in addition to confirming the sustained statistically significant improvements in lung function, roflumilast also showed a trend to reducing exacerbations when given in addition
Advice on managing "immune reconstitution inflammatory syndrome," a potentially dangerous over-activity of the immune system which can occur as formerly impaired immune responses rebound under treatment.
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Chronic inflammation in the lungs plays a significant role in COPD.